ABSTRACT
Objetivos. Descrever a frequência do uso do corticosteroide pré-natal e a avaliar a evolução dos recém-nascidos, comparando-se os desfechos com o tipo de corticosteroide usado. Método. Estudo observacional prospectivo do tipo coorte com neonatos de 26 a 34 semanas, nascidos de agosto de 2007 a julho de 2008. A análise dos dados foi feita com o programa SPSS, versão 16 para o Windows, sendo usado ostestes qui ao quadrado, t de Student, razão de risco com intervalo de confiança e regressão logística múltipla. O nível de significância foi 0,05.Resultados. Foram estudadas 187 mães, que conceberam 219 recém-nascidos, das quais 50,3% receberam corticosteroide. A hipertensão ocorreu mais nas gestantes que não receberam corticosteroide. Os recém-nascidos expostos a corticoterapia pré-natal apresentaram significativamente melhores condições ao nascer, menos morbidade como doença da membrana hialina, sepse, hemorragia intraventricular e menor necessidade do uso de ibuprofeno para o fechamento do canal arterial.Não foram observadas diferenças quanto à ocorrência de displasia broncopulmonar, pneumotórax, enterocolite necrosante, uso da ventilação mecânica, uso de surfactante exógeno e morte hospitalar. O corticosteroide pré-natal manteve-se de forma independente quanto ao efeito protetor para melhores condições de nascimento e para a ocorrência da sepse. A betametasona mostrou-se mais eficiente na redução da doença da membrana hialina. Conclusão. Os recém-nascidos submetidos à corticoterapia pré-natal apresentaram melhores condições ao nascer e tiveram menor morbidade.
Objectives. To describe the frequency of prenatal corticosteroids use and to evaluate the newborns development, comparing their outcome to the type of corticosteroids they used. Method. It is a cohort-type observational study with neonates from 26 to 34 weeks that were born from August 2007 to July 2008. The data analysis was accomplished by thesoftware SPSS for Windows, version 16,and the chi-squared test, t-Student test, risk ratio with confidence interval and multiple logistic regressionwere applied.Significance interval was p < 0.05. Results. In the cohort studied, 187 mothers gave birth to 219 newborns, from which 50.3% received corticosteroids. The pregnant women who were not treated showed significantly more hypertension. The newborns exposed to prenatal corticosteroids presented significantly better conditions at birth and a decrease on hyaline membrane disease, sepsis, intraventricular hemorrhage and decreased need of ibuprofen for the closing of the ductus arteriosus patent. There were no significant differences in the occurrence of bronchopulmonary dysplasia, pneumothorax, necrotizing enterocolitis, mechanical ventilation, use of exogenous surfactant and death during the hospitalization period. The prenatal therapywith corticosteroids remained as an independent protective factor for better conditions at birth and avoiding sepsis. The betametasone showed more efficiency in reducing the hyaline membrane disease.Conclusion. The newborns undergone prenatal therapy with corticosteroidsshowed better conditions at birth and thrived with less morbidity.
ABSTRACT
Plants of the genus Hypericum, long used in folk medicine, contain active compounds which present, anti-septic, diuretic, digestive, expectorant, vermifugal, anti-depressive and other properties. The possible clastogenic effect of a H. brasiliense extract was tested in vivo on the bone marrow cells of Wistar rats. The extract was administered by gavage at doses of 50, 150 and 300 mg/kg body weight. Experimental and control animals were submitted to euthanasia 24 h after the treatment for micronucleus (MN) and chromosome preparations. H. brasiliense extract did not induce statistically significant increases in the average numbers of MN or chromosome aberrations in the test systems employed.